pI: 5.0225 |
Length (AA): 384 |
MW (Da): 44678 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_130053)
Species | Accession | Gene Product |
---|---|---|
Drosophila melanogaster | Dmel_CG14905 | CG14905 gene product from transcript CG14905-RA |
Echinococcus granulosus | EgrG_000441000 | axonemal p66.0 |
Echinococcus multilocularis | EmuJ_000441000 | axonemal p66.0 |
Giardia lamblia | GL50803_114462 | Axonemal p66.0 |
Homo sapiens | ENSG00000173093 | coiled-coil domain containing 63 |
Homo sapiens | ENSG00000105479 | coiled-coil domain containing 114 |
Leishmania braziliensis | LbrM.32.3150 | outer dynein arm docking complex, putative;with=GeneDB:Linj32_V3.3050 |
Leishmania donovani | LdBPK_323050.1 | outer dynein arm docking complex, putative |
Leishmania infantum | LinJ.32.3050 | outer dynein arm docking complex protein;with=GeneDB:Linj32_V3.3050 |
Leishmania major | LmjF.32.2900 | outer dynein arm docking complex, putative;with=GeneDB:Linj32_V3.3050 |
Leishmania mexicana | LmxM.31.2900 | hypothetical protein, conserved |
Mus musculus | ENSMUSG00000040189 | coiled-coil domain containing 114 |
Mus musculus | ENSMUSG00000043036 | coiled-coil domain containing 63 |
Neospora caninum | NCLIV_037230 | hypothetical protein, conserved |
Schistosoma japonicum | Sjp_0013800 | Coiled-coil domain-containing protein 114, putative |
Schistosoma mansoni | Smp_000580 | hypothetical protein |
Schmidtea mediterranea | mk4.002554.00 | |
Schmidtea mediterranea | mk4.011127.00 | |
Schmidtea mediterranea | mk4.004618.00 | |
Schmidtea mediterranea | mk4.024286.00 | |
Trypanosoma brucei gambiense | Tbg972.11.18030 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.16090 | outer dynein arm docking complex, putative |
Trypanosoma congolense | TcIL3000.11.16010 | outer dynein arm docking complex, putative |
Trypanosoma cruzi | TcCLB.509073.40 | outer dynein arm docking complex protein |
Trypanosoma cruzi | TcCLB.508707.170 | outer dynein arm docking complex, putative |
Toxoplasma gondii | TGME49_269160 | outer dynein arm docking complex protein ODA1, putative |
Trichomonas vaginalis | TVAG_238220 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_120000 | protein NUF1, putative |
Trichomonas vaginalis | TVAG_026430 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_567400 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_456520 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.7750 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.7750 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.7750 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.7750 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_269160 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.